Based on the American cartoon, "The Powerpuff Girls." Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange black and white lights to scatter. The black lights turn its victims into monsters, with emphasis on a black light hitting a zoo monkey and transforming him into Mojo Jojo. The white lights, however, aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!

On a quiet and peaceful day, the skies split open and extradimensional beings, designated as the Unknown, launch a swift and brutal attack against humanity. To protect the future of the country, all of Japan's children are cryogenically frozen until the end of the war to keep them out of harm's way. Several years pass, and humanity has established a foothold in a corner of Japan, which now serves as the frontline of the war. No longer facing humanity's extinction, the children are awakened from their slumber. It is then discovered that, while in cryogenesis, the children had developed Worlds, supernatural powers unique to each person. The six most powerful children are given command of the reclaimed cities, using their powers to defend the strongholds against the continuing invasion. Childhood friends Ichiya Suzaku and Canaria Utara lead Tokyo, siblings Kasumi and Asuha Chigusa manage Chiba, and Maihime Tenkawa and Hotaru Rindou oversee Kanagawa. Over time, the almost routine attacks from the Unknown and the clashing personalities of the city heads and subheads cultivate petty rivalries, leading to constant arguments between the three cities. With the Unknown suddenly increasing the pressure of their attacks, the three cities' leaders must learn how to work together or risk losing the last line of defense against humanity's extinction. [Written by MAL Rewrite]

Nemeses—powerful and mysterious demonic entities that fall from the sky and vaporize anything they touch. The only ones who can combat these creatures are Sorcerers, those who have survived an encounter with a Nemesis but were infected in the process. Seth, a Sorcerer from Pompo Hills, sets out on an adventure to exterminate all these Nemeses. Accompanying him are Doc and Mélie, fellow Sorcerers who share his ideal. Their main objective is to bring about a world where Sorcerers are no longer persecuted for being infected, and to that end, desire to destroy the source of the Nemeses themselves: the mythical Radiant. [Written by MAL Rewrite]

Second season of Radiant.