Kyoshiro to Towa no Sora revolves around the life of Kuu Shiratori, a seemingly normal high school girl who enjoys her school life in the giant city Academia, which is thought of as a symbol of recovery for humanity since already ten years have passed since the greatest disaster mankind had ever seen, occurred. Kuu has recently been having a recurring dream where a prince meets her and takes her away. One day, while all the students at her school are preparing for the upcoming school festival, the prince, whom she has met several times in her dreams, appears. The prince, Kyoshiro Ayanokoji, requests of her just as he had done in Kuu's dreams, "Let's go... together..."

A great evil is sweeping over the realm; an evil that the young swordsman Roan and his life-long companion, the acolyte Yufa, must face head on! For these two travel toward their destiny, from the highest towers to the depths of the underworld, through forest and desert alike. With an ever-growing cast of fellow heroes, fate will grasp these travelers by their very souls and propel the band of skilled adventurers towards a noble end. Or ignoble, if they don't watch their step! Monsters are afoot and the way rife with danger and magic, the path forward may be unclear... But where will is strong, there is a way! Lessons wait in the depths of darkness, and good must prevail. The journey starts now!

Mikami Inaba was fighting a person from another school on her school's rooftop. As they fought, her friend Haru appeared. Seeing Mikami distracted, the man charged at her, causing both of them to break the nearby rabbit cages & fall off the roof. As Mikami fell, she desperately grabbed the rabbit. Suddenly, a flash or pink light appeared. Mikami fused with the rabbit, and gained another personality, called Mimika. Now, Mikami only appears when various people threaten her and her friends. Otherwise, she takes on the form of Mimika.

Due to her father's remarriage, robust 16-year-old Himeno Awayuki moves into a large mansion with a beautiful garden—the quintessential dream house for any girl her age. However, much to Himeno's disappointment, her new stepfamily doesn't really seem to like her, as her stepmother often occupies herself with her father, her younger stepsister Mawata ignores her, and her other stepsister—the equally aged Mayune—tries to prank her at every opportunity. But Himeno doesn't have time to dwell into thoughts of hopelessness—her new life has now become involved with a group of seven magical boys known as the Leafe Knights, after they ask her to become a magical princess who can borrow their powers! Although Himeno accepts their request and becomes the Prétear, she feels doubtful in her abilities to protect the world and its Leafe, the source of energy for all life. Will Himeno be able to find happiness among her new family and also save the Earth from the enemy, the Princess of Disaster?