-ADVERTISEMENT- With the conclusion of her favorite romance manga, Fuuko Izumo is ready to end her life of misery and loneliness having long accepted her fate of never being able to experience passionate love like fictional characters. Cursed with "unluck," anyone Fuuko touches is in grave danger of experiencing unimaginable calamity. While the possibility of imminent danger would have most sane people run in the opposite direction, Undead has other ideas. He is an immortal being with superhuman regenerative powers desperately seeking death, which has always eluded him. When their paths finally cross, Undead sees an opportunity to finally end his suffering by using Fuuko's unluck. But before Undead can unlock the full potential of Fuuko's power to trigger the final devastating blow, the duo must first fend off a murderous secret organization hell-bent on exterminating those with special abilities.

Maomao, an apothecary's daughter, has been plucked from her peaceful life and sold to the lowest echelons of the imperial court. Now merely a maid, Maomao settles into her new mundane life and hides her extensive knowledge of medicine in order to avoid any unwanted attention. Not long after Maomao's arrival, the emperor's infant children inexplicably begin to experience grave symptoms—almost as if a curse has been cast. The curious Maomao easily solves the mystery and, to remain out of the limelight, attempts to leave an anonymous tip. Unfortunately, the dashing and perceptive eunuch Jinshi sees through it and manages to single her out. In recognition of her talent, Maomao is promoted to lady-in-waiting for the emperor's favorite concubine, Gyokuyou. As Maomao continues to remedy the numerous ailments afflicting the imperial court, her pharmaceutical expertise quickly proves indispensable.

Ryuuto Kashima is a gloomy high schooler. As part of a punishment game, he was forced to confess to Runa Shirakawa, a girl from the top of the school caste who was admired by everyone. They ended up going out for the unexpected reason of "Err, I'm free now so..." but Ryuuto ends up following and eavesdropping on Runa being confessed by a handsome soccer club member, and Runa bringing Ryuuto, whom she had just begun dating, to her own room as a matter of course. They have different friends and ways to have fun, and they are different in almost every way. Nonetheless, they begin to relate with each other after being surprised by their differences every day and accepting them.

The second season of Saihate no Paladin. Two years had passed since he left the City of the Dead, and Will was seventeen by count. As a lord, he developed "Torch Port, a river port of light", and gradually the people's activities and smiles returned to "Beast Woods". However, out-of-season flowers bloom profusely, and an abnormality is discovered in the forest. Will and his friends head into the depths of the forest to solve this problem, and receive an ominous prophecy from the king of the forest. "In the Iron Rust Mountains, the 'Fire of Black Calamity' will occur. The fire will spread, or it will burn everything in this land." What is the calamity that sleeps in the ruined dwarven city of Tetsusabi Sanmyaku...!?