The anime centers on four girls at the full bloom of their youth, working hard to achieve their dreams as they struggle valiantly. In Japanese entertainment, Maesetsu! refers to an introductory talk or explanation addressed to the audience before the broadcast of television programs, usually performed by assistant directors and particularly comedians in variety or comedy shows.

Project Scard depicts the encounters and battles of those who have tattoos which possess the sealed powers of divine beasts and gods. The story is set in the Akatsuki Special Zone, a lawless zone in Tokyo. "Helios" are those who use the ability of the tattoos to protect the city, "Artemis" are committed to maintain security and control, whilst having a strong commercial motive, and the "Public Security Special Service" are Scard Staff of the metropolitan police department. They live through the turbulent days to keep on going. (Source: MAL News)

First loves are messy. While settling in as a shoujo manga editor at the famous Marukawa Publishing House, Ritsu Onodera is quite troubled. Working under the stern and superb Masamune Takano is hard enough as it is. However, Masamune is not only Ritsu's first love from middle school but he also suddenly declares that he will make Ritsu fall for him again. Unknown to them, another editor in the department, Yoshiyuki Katori, is in a relationship with the popular manga artist Chiaki Yoshino. The carefree Chiaki fails to notice, however, that his high school friend—Yuu Yanase—thinks of him as more than a friend. The stoic but caring Hatori will not surrender his love so easily. Falling in love for the first time when you are 30 is certainly troublesome. Shouta Kisa, yet another editor, is going out with 21-year-old Kou Yukina, an art student. Despite Yukina's assurances, Kisa cannot help but doubt whether someone like himself is truly worthy of his younger, "sparkling" boyfriend.

After having to deal with jealousy from his co-workers for working under his father's name, prideful literary editor Ritsu Onodera is determined to establish himself in the industry. To accomplish this, he quits his job at his father's publishing company and transfers to Marukawa Publishing. But instead of being placed in their literary division, Ritsu finds himself working as the rookie manga editor for the Emerald editing department, a team that operates under extremely tight schedules in order to meet deadlines. There, Ritsu is introduced to the infamous editor-in-chief Masamune Takano, a persistent man who strives for results. As it turns out, Takano is actually Ritsu's high school love, and it is the aftermath of that heartbreak has caused Ritsu's reluctance to fall in love again. Now with the two reunited after several years of separation, the reestablishment of their relationship is marked by Takano's vow to make Ritsu say that he loves him again. Sekaiichi Hatsukoi follows three couples that are interconnected within the manga industry, with each being subject to the budding of first love.