In Tokyo Fire Department's Fire Academy, a talented new rookie is excelling in the strict and grueling rescue training. With high proficiency in both physical and mental categories, Daigo Toake is envied by one of his peers, Shun Onoda. Despite feeling a growing sense of rivalry, Shun recognizes that a part of his jealousy stems from his admiration for Daigo, and that they will eventually work together for the same noble goal of rescuing people. At the same time, Yuki Nakamura is the only woman among the current batch of recruits. She believes that she will not be outclassed in this male-dominated profession. As the fates of the three newbies intertwine, they may soon realize that the intensity of a real disaster is nowhere near what they have experienced in training. Even so, the heroes in orange will always shine brighter than any fire, saving those in need.

Nekoma High School’s volleyball team recruits a new member: the half-Japanese, half-Russian Lev Haiba. Though the self-proclaimed ace is blessed with great height, he lacks basic volleyball techniques. This gives the team's setter, Kenma Kozume, a hard time when matching up with him. To everyone’s surprise, Nekoma’s coach suggests that Lev play in the Kunihira Senior High School’s practice match, leaving Kenma no choice but to cooperate with the tall player. Will Kenma be able to overcome this new challenge?

The story takes place in Japan. The year is 2030 and Earth has been completely overrun by a viral disease named "Gibia" that turns infected people into various different monsters, based on their age, sex, and race. A samurai and a ninja from the early Edo period travel together through time and arrive in a ruined Japan to aid a professor working on a cure for the virus. Together, they fight countless Gibia monsters, outlaws, and other fierce foes on their journey to save mankind.

A young girl named Zuru sets out on an expedition through a post-apocalyptic city controlled by machines in a desperate hunt for food. Things go awry when her team accidently triggers the city's AI defense program called the Safeguard. Attacked by the machines, her companions are on the verge of being annihilated when a mysterious man named Killy arrives and exterminates the hostile units.

Despite his heroic intervention, Zuru is hesitant to trust Killy and questions his motives. He reveals to have come from thousands of levels below the city in order to find humans possessing the Net Terminal Genes—a trait that would allow humans to regain control of their civilization and shut down the Safeguard. After hearing his story, Zuru and the rest of her team join Killy and embark on a journey in search of the Genes that could prove to be mankind's last hope of survival.

[Written by MAL Rewrite]