This sequel to the Silent Mobius The Movie 1 continues the timeline of the flashback section of the first movie (Katsumis initial contact with AMP), using some more ideas and persons from the Manga, and being slightly less incompatible to the Silent Mobius series from 1998.

Midori Asakusa sees the world a bit differently. Always having her nose in a sketchbook, Asakusa draws detailed landscapes and backgrounds of both the world around her and the one within her boundless imagination. Even the simple act of doodling on a wall evolves into an emergency repair on the outer hull of her spaceship. She is only brought back to reality by her best friend Sayaka Kanamori. The pair are stark opposites, with Asakusa's childlike wonder contrasted by Kanamori's calculated approach to life. After a chance encounter where the two "save" the young model Tsubame Misuzaki from her overprotective bodyguard, a connection instantly sparks between Asakusa and Misuzaki, as both share an intense passion for art and animation. Whereas Asakusa is interested in backgrounds and settings, Misuzaki loves drawing the human form. Sensing a money-making opportunity, Kanamori suggests that they start an animation club, which they disguise as a motion picture club since the school already has an anime club. Thus begins the trio's journey of producing animation that will awe the world. From the brilliant mind of Masaaki Yuasa, Eizouken ni wa Te wo Dasu na! is a love letter to animation, wildly creative in its approach, and a testament to the potential of the medium.

In the past, humanoid bears coexisted with humans. However, a meteor shower that fell onto Earth had a strange effect on bears throughout the world: they suddenly became violent and hungry for human flesh, spurring an endless cycle of bloodshed in which bear ate man and man shot bear, forgetting the lively relationship they once had. The "Wall of Severance" was thus built, separating the two civilizations and keeping peace. Kureha Tsubaki and Sumika Izumino are two lovers attending Arashigaoka Academy, who, upon the arrival of two bears that have sneaked through the Wall of Severance and infiltrated the academy, find their relationship under a grave threat. The hungering yet affectionate bears, Ginko Yurishiro and Lulu Yurigasaki, seem to see the bear-hating Kureha as more than just another meal, and in getting closer to her, trigger an unraveling of secrets that Kureha may not be able to bear. When their relationships provoke the Invisible Storm, a group that keeps order within the ideological school, the girls must stand on trial with their love, embarking on a journey of self-discovery en route to attaining true love's "promised kiss."

Filled with rage against spirits known as tsukumogami, Kunato Hyoma is sent to live with Nagatsuki Botan to help him see a different side. Though both are part of a clan that return the spirits back to their world with divine powers, their experiences with the otherworldly vessels are vastly different. Kunato, robbed of a loved one, and Nagatsuki, saved by them. Can she get through to him?