On the 20th floor of the Tower, the "Regulars" who have been permitted to enter have to undertake arduous and extremely expensive tests to rank up. Most abandon hope and choose to stay where they are—but not Ja Wangnan. Wangnan is determined to reach the top and become the king of the Tower. However, he is weak and has repeatedly failed the exam, with debt collectors tailing him. In desperation, he attempts the exam one more time, only to encounter a mysterious and powerful individual: Jyu Viole Grace, a member of the crime syndicate FUG. Cursing his rotten luck, Wangnan has no choice but to form alliances with strong people, including Viole—who still refuses to be part of any team. Amid a dire situation, Wangnan must find a way to change Viole's mind to finally advance past the 20th floor, or he will never get a chance to build his legacy.

Not long after forming their partnership, detectives Ron Kamonohashi and Totomaru Isshiki have proven adept at solving various cases together. However, the two are further motivated to continue their work when they discover that the House of M—an infamous crime syndicate—orchestrated Ron's expulsion from the prestigious Detective Training Academy BLUE five years prior. It appears that this group is also linked to Ron's mysterious ability that causes those around him to lose their lives, a phenomenon which Ron is desperate to stop. A member of the House of M soon starts to commit boastful serial murders around Shibuya as an act of provocation toward Ron. Consequently, the investigative pair must do their best to apprehend the culprit for the sake of justice as well as learning more about Ron's dark past and present condition.

According to an ancient legend, mermaid's flesh can grant immortality if eaten. 500 years ago, Yuta unknowingly ate a piece of mermaid's flesh. For centuries, he travels across Japan, hoping to find a mermaid, thinking she may be able to make him a normal human again. When he finally finds one, he discovers that she and her companions have been raising a girl to be their food so they can eat her and take on her youthful looks. That is how mermaids stay young. Yuta kills the mermaids and rescues her, but she has already eaten some of the mermaid's flesh. Although he had to kill the mermaids, Yuta isn't too disappointed. Yuta's once lonely existence is now over, as he has found a companion in Mana. And Mana, who had been trapped in a small hut her whole life, finds delight in even the simplest of things. Together, Yuta and Mana attempt to seek out more mermaids, trying to become normal humans again.

Asa and Kame strike up an immediate friendship when they arrive at the same time for their first day of duty at the Ooku, the splendid pleasure palace housing the harem of Lord Tenshi. The two young women are there to join the many hundreds of other maidservants—men are barred from entering, with immediate beheading the price of trespassing. It soon becomes clear that behind the luxurious lifestyle and ritualized routines of the Ooku lie sinister schemes and cynical rivalries. Meanwhile, a mysterious wandering potion-peddler known only as the Medicine Seller subtly insinuates himself into the Ooku, just as an uncanny, otherworldly menace begins to reveal itself.