Dr. Slump creates a little android girl, Arale, who is very stong, happy, and totally common senseless. They live in Penguin Village where the strangest things happen (e.g., the dawn is announced by a little pig wearing a basquee).

In the anime, Kuromi is traveling the world, searching for her missing older sister Romina. Throughout her journey, she gains companions, but also brushes up against evil organizations.

After losing her parents in a car accident, Okko goes to live in the countryside with her grandmother, who runs a traditional Japanese inn built on top of an ancient spring said to have healing waters. While she goes about her chores and prepares to become the inn's next caretaker, Okko discovers there are ghosts who live there that only she can see – not scary ghosts, but playful child ghosts who keep her company and help her feel less lonely. A sign outside says the spring welcomes all and will reject none, and this is soon put to the test as a string of new guests challenge Okko's ability to be a gracious host. But ultimately Okko discovers that dedicating herself to the happiness of others becomes the key to taking care of herself.

Nasa, at the request of his former junior high school teacher, Ms. Yanagi, finds hisself entrusted with teaching a programming class at a high school. But here's the catch—it's an all-girls' school. Surrounded by the limitless energy of teenage girls, Nasa tries to maintain his composure, but deep down, he can't help feeling nervous. A capricious boyfriend, secret admiration for someone, and a multitude of romantic dilemmas that can't be solved by programming, Nasa wonders if he can crack the equation of love!